过去一年中添加的文章，按日期排序
Advancing Toxicity Predictions: A Review on in Vitro to in Vivo Extrapolation in Next-Generation Risk Assessment
P Han, X Li, J Yang, Y Zhang, J Chen - Environment & Health, 2024 - ACS Publications
6 天前 - … this approach substantially increased after the European Union (EU) and United
States (US) regulatory … utilized in vitro toxicity data to predict multiple in vivo toxicity end points, …
States (US) regulatory … utilized in vitro toxicity data to predict multiple in vivo toxicity end points, …
Abstract PO4-14-05: Germline and acquired genetic variants and long-term cancer-related fatigue among survivors of early-stage breast cancer (BC)
12 天前 - … , longitudinal CANcer TOxicity cohort, … driven approach, we investigated (i)
germline genetic variants in a pre-specified Genetic Risk Index (GRI) assaying expression-regulating …
germline genetic variants in a pre-specified Genetic Risk Index (GRI) assaying expression-regulating …
Abstract PO5-16-12: EFFICACY AND TOLERABILITY OF METRONOMIC CHEMOTHERAPY (mChT) WITH CYCLOPHOSPHAMIDE, METHOTREXATE AND …
C Saavedra, M Gion, A Cortés, P Cortez, L Garrigós… - Cancer Research, 2024 - AACR
12 天前 - … and immune-regulation. mChT has demonstrated promising clinical activity and low
toxicity in patients with … while for survival analysis Kaplan Meier approach was employed. …
toxicity in patients with … while for survival analysis Kaplan Meier approach was employed. …
Lung-targeting Nox4 Inhibitors as a Novel Strategy for Age-dependent Severe ARDS
L Hecker, K Kato, AR Waich, C Coarfa… - B28. LUNGS …, 2024 - atsjournals.org
13 天前 - … analyses was used to evaluate Nox4 transcriptional regulation in … approach
boosts bioavailability of Nox4 inhibitor within the lung while reducing the risk of systemic toxicity, …
boosts bioavailability of Nox4 inhibitor within the lung while reducing the risk of systemic toxicity, …
Integrated In Vitro/Ex Vivo Assessment of Efficacy and Respiratory Toxicity for Accelerated Respiratory Drug Development
K Schwarz, F Dahlmann, D Winterberg… - B67. VIRAL …, 2024 - atsjournals.org
13 天前 - … We have developed an integrative approach for early evaluation of new inhaled
anti-… 28-day regulatory inhalation toxicological study was performed in rats in parallel. Data …
anti-… 28-day regulatory inhalation toxicological study was performed in rats in parallel. Data …
Quantifying disparities in per-and polyfluoroalkyl substances (PFAS) levels in drinking water from overburdened communities in New Jersey, 2019–2021
R Mueller, D Salvatore, P Brown… - … Health Perspectives, 2024 - ehp.niehs.nih.gov
19 天前 - … ), the first US state to develop regulatory levels for PFAS in … regarding the widespread
exposure and toxicity of per- and … In this study, we use 2019–2021 CWS testing data from …
exposure and toxicity of per- and … In this study, we use 2019–2021 CWS testing data from …
Enhanced Risk Assessment of Transformation Products through Chemical Similarity Analysis
P Löffler, A Lai, H Henschel, F Spilsbury… - ACS ES&T …, 2024 - ACS Publications
26 天前 - … systematically identified during regulatory risk assessment of … used toxicity end
points of the parent compound for risk assessment purposes (termed the “read-across approach”)…
points of the parent compound for risk assessment purposes (termed the “read-across approach”)…
Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century:“What Are the Tools Needed for the Job?” and “Do We …
43 天前 - … New approach methods (NAMs) in the field of toxicology … ENDS use on human health
slows the application of regulatory … currently available sources of data, their applicability to …
slows the application of regulatory … currently available sources of data, their applicability to …
Evaluation of a Proportional Response Addition Approach to Mixture Risk Assessment and Predictive Toxicology Using Data on Four Trihalomethanes from the US …
LK Teuschler, RC Hertzberg, A McDonald, YM Sey… - Toxics, 2024 - mdpi.com
50 天前 - … dose-addition use statistical modeling of the data, such as … the toxicity of one
component does not impact the toxicity of … recommended for use by any regulatory agency and this …
component does not impact the toxicity of … recommended for use by any regulatory agency and this …
Mechanistic insight into mTOR signaling identifies RNA splicing machinery as a potential therapeutic target for cancer
53 天前 - … of action and long-term toxicity. Treated cells were also … events and regulators
revealed mTOR regulation of mRNA … These results support the use of this approach for further …
revealed mTOR regulation of mRNA … These results support the use of this approach for further …